Category Archives: Suprellin Histrelin puberty blockade

What if Jazz stayed on Supprelin (histrelin) until she was 30

July 6, 2017

Good morning T,

From what I have learned the effects of puberty blockers are
reversible.  In all honesty don’t know of anyone who has taken them
that long.  On the other hand it is conceivable that chronic
suppression of the primary gland could cause irreversible atrophy.

From the web…

Histrelin acetate is a gonadotropin releasing agonist (stimulates release of gonadotropins).  Supprelin works on the hypothalamus to over-actively stimulate gonadal tropic releasing hormones which eventually and counter-intuitively leads to suppression, resulting in hormones stimulation blockage.  Initially in some patients there could be a brief rise in male or female puberty characteristics.The (Supprelin) histrelin implant is approximately $15,000 total for the device and the cost of surgically implanting it in the arm.  The tubing which contains the
hormone blocker is about 1 1/2 inches long and is flexible.

Also, labs need to be monitored while on these agents. A pre-treatment LH, FSH and testosterone or estradiol level is checked, as well as a post treatment level to assess the level of suppression.

Some health insurance will cover them partially in cross gender treatment, and some won’t. As a result, the out of pocket cost of these agents can be quite substantial.


What If the Child Has Already Begun Puberty?

Even better. 🙂 Actually one has to be in the second stage of puberty to demonstrate that there is puberty to suppress. LH and FSH need to be elevated in order to prescribe these agents. Then the levels are checked again after treatment to make sure they have decreased.

Being on these medications will cause breast reduction in female bodied persons. They will not reduce or stop the growth of pubic hair, axillary hair or acne. In male bodied persons, testicular size will decrease, phallic growth will stop, but not regress. The frequency of spontaneous erections and wet dreams goes down significantly. Still, the person will have pubic hair, axillary hair and acne from the adrenal glands.


Harold M. Reed, M.D.