Dr. Reed, I am transition male to female. If an orchiectomy is done now, will I be able to stop testosterone blockers and what effect will this have on my general well being?
We have done a few thousand orchiectomies for male to female transgender patients over the years. The advantages are stopping testosterone blockers, and in general reducing your estrogen intake by a third. You will still have ample enough surface area in your scrotum to provide vaginal extension of inverted penile skin. Your adrenal glands will still make still make testosterone and testosterone like hormones..
Quantitatively, women secrete greater amounts of androgen than of estrogen. The major circulating steroids generally classified as androgens include dehydroepiandrosterone sulphate (DHEAS), dehydroepiandrosterone (DHEA), androstenedione (A), testosterone (T), and dihydrotestosterone in descending order of serum concentration, though only the latter two bind the androgen receptor. The other three steroids are better considered as pro-androgens. Dehydroepiandrosterone is primarily an adrenal product, regulated by adrenocorticotropic hormone (ACTH) and acting as a precursor for the peripheral synthesis of more potent androgens. Dehydroepiandrosterone is produced by both the ovary and adrenal, as well as being derived from circulating DHEAS. Androstenedione and testosterone are products of the ovary and the adrenal. Testosterone circulates both in its free form, and bound to protein including albumin and sex steroid hormone-binding globulin (SHBG), the levels of which are an important determinant of free testosterone concentration. (with credit to
Natal women on average outlive men by about 5 to 6 years. I think the choice of a transitional orchiectomy is yours. Consider us for an affordable male to female orchiectomy.
With kindest regards,
Harold M. Reed, M.D.
The Reed Centre for Transgender Surgery – Miami